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KMID : 1123920200340010007
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Korean Journal of Oriental Physiology and Pathology
2020 Volume.34 No. 1 p.7 ~ p.13
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Effect of Sanyeoleumja on Inflammatory Response of RAW 264.7 Cells
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Kim Tae-Yeon
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Abstract
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Sanyeoleumja (SY) is the traditional Korean medicinal prescription for the treatment of inflammatory diseases of eyes. In this study, the anti-inflammatory effects of SY water extract were investigated. To measure the anti-inflammatory effects of SY, we examined the productions of inflammatory factor including nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), interleukin-1β (IL-1β) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. SY inhibited NO and PGE2 production in a dose dependent manner and decreased the protein and mRNA expression of iNOS and COX-2. Also, SY decreased the mRNA expression of interleukin-6 (IL-6) and interleukin-1β (IL-1β). In conclusion, SY downregulated LPS-induced inflammatory factor productions, which could be a clinical basis for inflammatory diseases.
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KEYWORD
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Sanyeoleumja (SY), Anti-inflammatory, Inflammatory factor, NO, PGE2
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